ACE2 and infection: Moreover, as SARS-CoV-2 depletes Angiotensin-Converting Enzyme 2 (ACE-2) causing a significant renin-angiotensin system disequilibrium, it is thought that, following the infection, a prothrombotic state with impaired large vessel and microvascular blood flow can occur and lead to increased risk of thrombotic and hemorrhagic stroke [11].