The meta-analysis results between XRCC3 Thr241Met polymorphism and leukemia susceptibility are shown in Table 2.Generally, positive finding between leukemia and XRCC3 Thr241Met polymorphism was found in Caucasian population by allele contrast (T vs. C: OR 1.20, 95% CI 1.02–1.40, P = 0.026, Fig. 1), homozygote comparison (TT vs. CC: OR 1.35, 95% CI 1.05–1.73, P = 0.018, Fig. 2), and recessive genetic model (TT vs. TC/CC: OR 1.31, 95% CI 1.04–1.64, P = 0.023, Fig. 3). Here, XRCC3 is linked to leukemia.