PM contains volatile mixtures of numerous heavy metals, organic compounds, and carcinogens that interact with in vivo cellular mechanisms and induce vascular damage, including endothelium inflammation, development of atherosclerosis, lipid peroxidation, alterations in cytokines and acute phase protein levels (such as CRP), and procoagulant responses [41, 42]. The gene discussed is CRP; the disease is atherosclerosis.