As well as miR-375-3p and miR-874-3p, miR-375-3p was found to suppress tumorigenesis by targeting YAP1 and SP1 in colorectal cancer cells [28], and alleviate the severity of inflammation through targeting YAP1/LEKTI pathway in HaCaT cells [29], miR-874-3p was found as an anti-oncomir in esophageal squamous cell carcinoma via targeting STAT3 [30]. This evidence concerns the gene SPINK5 and colorectal cancer.