TRPC3 and Spinocerebellar ataxia type 41: Mwk mouse is a spontaneous mutant mouse that shows abnormal Purkinje cell development and cerebellar ataxia due to increased calcium influx to Purkinje cells through mutated TRPC3 channels (Becker et al., 2009), and TRPC3 was also identified as the gene causing SCA41 (Fogel et al., 2015).