Moreover, the polyclonal IgE produced following S. aureus superantigen exposure can contribute to the persistent type 2 inflammation associated with CRSwNP through continuous mast cell activation, and the elevated specific polyclonal IgE to S. aureus enterotoxins in the serum of these patients is a known risk factor for asthma severity [23]. Here, IGHE is linked to chronic rhinosinusitis with nasal polyps.