AR is defined as rhinitis or rhinoconjunctivitis where symptoms, including nasal congestion, nasal itch, rhinorrhea, and sneezing, present following exposure to an aeroallergen, most commonly dander, mold, pollen, or residues from cockroaches and dust mites, with evidence of specific IgE to that allergen detected by SPT or serum-specific IgE testing [53]. This evidence concerns the gene IGHE and rhinitis.