In a large community-based study, including over thirteen thousand individuals participating within the community-based Atherosclerosis Risk in Communities (ARIC) study, higher baseline FGF23 levels are associated with increased risk of developing end-stage kidney disease (ESKD) after a follow-up of up to 21 years even after adjustment for demographic characteristics, baseline eGFR, traditional risk factors for CKD, and markers of mineral metabolism [13]. Here, FGF23 is linked to chronic kidney disease.