The promotor of FGF23 has two binding sites for the transcription factor nuclear factor of activated T cells (NFAT); thus, NFAT is identified as a local regulator of FGF23 expression that is upregulated in the bone of CKD mice due to calcium and inflammatory stimuli [6], suggesting an induction of FGF23 mRNA expression. The gene discussed is FGF23; the disease is chronic kidney disease.