X-linked hypophosphatemia which is due to mutations in the phosphate regulating endopeptidase homolog X-linked (PHEX) gene is associated with elevated FGF23 serum levels, but there is no evidence for cardiovascular calcifications except patients receive excessive doses of oral phosphate promoting tertiary hyperparathyroidism [26, 27]. Here, PHEX is linked to X-linked hypophosphatemia.