Interestingly, FGF23 itself activates the calcium-dependent calcineurin/NFAT pathway in cardiac myocytes promoting pathological cardiac remodeling [7], and cardiac myocyte-specific calcineurin transgenic mice show elevated FGF23 with severe left ventricular hypertrophy (LVH) [8], indicating a connection between activated calcineurin/NFAT signaling pathway and high FGF23 levels. Here, FGF23 is linked to left ventricular hypertrophy.