By performing a comparative transcriptome analysis in kidneys of mouse CKD models with elevated FGF23, Dai et al. identified FGF23-responsive transcripts associated with kidney damage and chronic inflammation, such as lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), transforming growth factor-beta (TGF-β), and TNF-α [15]. The gene discussed is FGF23; the disease is chronic kidney disease.