While hematopoietic tumors express CD1d, many solid tumors are CD1d negative but can nonetheless be targeted by other mechanisms, including NKG2D engagement [27, 37, 42], or by indirect activation of iNKT cells by other CD1d‐expressing, antigen‐presenting cells present within the tumor microenvironment [31]. The gene discussed is KLRK1; the disease is neoplasm.