From a mechanistic point of view, iNKT cells, similarly to other cytotoxic populations, are known for inducing tumor cell death both by granzyme B/perforin production and by expression of Fas ligand (FasL) and TRAIL on their plasma membranes [38, 42, 44, 61, 62, 63]. The gene discussed is TNFSF10; the disease is neoplasm.