Eight of the enriched BD genes were NCAN, TENM4 (previously named ODZ4), FBLN1, ZMIZ1, NFIA, ZSWIM6, DOK5, and SLC45A4. Expression of all eight of these BD risk genes was significantly changed in astrocytes after TCF7L2 KD (Fig. 5b). Here, TCF7L2 is linked to Behcet disease.