CRP and major depressive disorder: This demonstrated a highly significant difference in the distribution of PD (right-shifted) in high CRP (> 3 mg/L) versus low CRP (< 3 mg/L) depression cases (Kolmogorov-Smirnov test, P < 6.4 × 10−7) and between high CRP depresssed cases and controls (Fig. 1A).