Two peaks were clearly identified at −1200 bp (referred to enhancer because of its negativity for H3K4me3 and positivity for H3K4me1) and −80 bp (promoter, H3K4me3 positive, H3K4me1 negative) from RAG1 transcription starting site (TSS), in all the samples (BCP-ALL patients, Nalm6 and REH cells) and shared for RUNX1 and ETV6-RUNX1 (Fig. 1D, Supplementary Fig. S2C). This evidence concerns the gene RAG1 and acute lymphoblastic leukemia.