Our study successfully demonstrated the existence of a new SEP-encoding oORF on the cell polarity-determining scaffold protein gene Scribble (SCRIB), which is considered a proto-oncogene with tumor suppressor function in antitumorigenic Hippo-YAP/TAZ, Ras/Raf/MEK/ERK (MAPK/ERK), and PI3K/Akt/mTOR and proapoptotic c-Myc-induced signaling pathways22–29. Here, MTOR is linked to neoplasm.