Recently, our lab has demonstrated the COX-2 induced DGLA peroxidation in D5D knockdown (siRNA/shRNA/3-way junctional (3WJ) D5D siRNA nanoparticle) cells and resulting in cancer growth inhibition against colon, pancreatic, lung, and breast cancer by 8-HOA production12–17. The gene discussed is PTGS2; the disease is breast cancer.