Cancer cell migration is a complex mechanism that necessitates coordination between specific cellular processes such as aggregation and dispersal of focal adhesions (FAs), polymerization of the actin filament, etc.45 The FA formation is commenced by the interaction of integrins with corresponding ligands followed by recruitment of various proteins such as focal adhesion kinase (FAK), vinculin, and paxillin45. Here, VCL is linked to cancer.