In contrast, METTL3-deficient NK cells from tumor-bearing mice exhibited remarkably decreased protein expression of CD107a, GzmB and IFN-γ than METTL3-sufficient NK cells (Fig. 4g–l), indicating METTL3 deficiency-mediated inhibition of cytotoxicity and cytokine production of NK cells in the TME. This evidence concerns the gene IFNG and neoplasm.