To further confirm the role of METTL3 in NK cell-mediated anti-tumor immunity, we depleted NK cells in WT mice or cKO mice by using anti-asialo-GM1 (ASGM1) or anti-NK1.1, followed by intrasplenic injection of MC38 cells (Supplementary Fig. 4A, C). The gene discussed is METTL3; the disease is neoplasm.