METTL3 and neoplasm: To investigate if METTL3 is required for NK cell-mediated anti-tumor immunity, we generated Mettl3fl/fl-Ncr1Cre/+ (cKO) mice, which harbored a selective deficiency of METTL3 expression at the mRNA or protein level in NK cells, with no change in METTL3 protein expression of T and B cells (Supplementary Fig. 3A–D).