Consistent with the observations of tumor-infiltrating NK cells, downregulation of METTL3 protein level in NK92 cells induced decreased expression of activation receptors, such as CD69, NKp30, and NKG2D, the transcription factor T-bet, and IFN-γ (Supplementary Fig. 2C, D). The gene discussed is METTL3; the disease is neoplasm.