HRH2 and liver disorder: As nizatidine had no effect on HRH2 expression in cell lines or 3D spheroids (Fig. 3i and Supplementary Fig. 9), we assume that the observed downregulation of HRH2 in nizatidine-treated animals is most likely not due to a direct effect of nizatidine on HRH2 expression, but rather due to the improvement of liver disease.