In the NASH-fibrosis mouse model the reduction of inflammatory immune cell recruitment leads to a decrease in the expression of interleukin 6 (Il6) and chemokine ligand 2 (Ccl2), two pro-inflammatory cytokines contributing to liver disease progression and HCC development34 (Supplementary Fig. 13). Here, CCL2 is linked to metabolic dysfunction-associated steatohepatitis.