SHANK3 and Alzheimer disease: In this study, we conduct a comparative analysis of the two models (the Shank3 model of ASD [31] and the P301S model of AD https://www.sciencedirect.com/science/article/pii/S089662730700030X) to investigate the shared biological processes (BP) and pathways that might be affected by aberrant SNO signaling in neurodevelopmental and neurodegenerative disorders.