The yellow-ASD and green-AD nodes in Fig. 3 correspond to the SNO proteins that are involved in “Modulation of chemical synaptic transmission”, including SYN1, STX1A, JAK2, and others in ASD (Fig. 3A) and TBCD, RAC1, P2RX3, SYT14, and others in AD (Fig. 3B). This evidence concerns the gene P2RX3 and Alzheimer disease.