ATXN3 and Spinocerebellar ataxia type 3: Unlike previous genome-editing studies of CRISPR/Cas9 in SCA3/MJD, paired sgRNAs and HR strategy are used for the first time to repair the abnormal CAG expansions in the exon 10 of ATXN3 in SCA3-iPSCs, which can avoid the problems caused by the NHEJ repair induced truncated ataxin3.