Pollens are considered a well-known allergy trigger and it has been reported that higher pollen-specific IgE is found in tears of AC patients than those of controlled subjects22, while pollen-Tear-specific IgE in AC patients reveals negative results in serum, indicating that local allergic sensitization response is activated and the conjunctiva might have contributed to the synthesis of local IgE30. This evidence concerns the gene IGHE and Allergy.