Although the involvement of AMPKα2 in the regulation of myocardial fibrosis and cardiolipin biosynthesis and maturation requires further studies, our results highlight a higher dependence on AMPK signaling for these processes in males, either due to the absence of female hormones protection or to counteract the action of male hormones, and that may contribute to the known difference in cardiovascular risk and outcome between sexes. Here, PRKAA2 is linked to Myocardial fibrosis.