HGS and neoplasm: Research on HRS protein has shown that the expression of dendritic cells defective in its expression, HGS gene (encoding HRS protein) knocked out HEK293 cell line and tumor cells, the release of exosomes is reduced, while silencing two genes that regulate HRS protein (HGS, STAM1) and the gene that regulates ESCRT-1 protein (TSG101) will reduce the release of EVs, which proves the important role of ESCRT protein in the biosynthesis and secretion of EVs [29].