Mutation in RNF43 is more frequent than ZNRF3 and its associated repercussions are pancreatic tumors called intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, colorectal adenocarcinomas, pancreatic cancer, gastric cancer, mucinous ovarian carcinoma, and endometrial carcinomas. The gene discussed is ZNRF3; the disease is pancreatic neoplasm.