Hyperglycaemia also causes oxidative stress through inhibition of the antioxidant function of thioredoxin by Thioredoxin-interacting protein (TXNIP), an oxidative stress-responsive and glucose-inducible gene because it is a carbohydrate response element in its promoter and it is overexpressed in both diabetic animals and humans [40]. The gene discussed is TXNIP; the disease is Hyperglycemia.