Interestingly, adiponectin is one of the most important adipocytokines secreted by adipocytes that is inversely associated with visceral adiposity and body fat mass and it can trigger plethora of signaling pathways like mitogen-activated protein kinase (MAPK), adenosine monophosphate-activated protein kinase (AMPK) and phosphoinositide 3-kinase (PI3K)/Akt resulting to inhibition of tumor formation induction. This evidence concerns the gene PIK3CA and neoplasm.