Additionally, the obesity induced inflammatory effects may promote cancer cell survival and further progression via enhanced generation of systemic inflammatory responses such as interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-α, cyclooxygenase-2, plasminogen activator inhibitor-1, fibrinogen, C-reactive protein and others [81, 82]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.