INS and type 2 diabetes mellitus: The first generation SU drugs like tolbutamide and chlorpropamide (Fig. 2) are no longer in use, while second generation SU drugs such as glibenclamide, gliclazide, glipizide and glimepiride (Fig. 2) are currently in use as antidiabetic drugs for the management of type 2 diabetes where they increase the release of insulin from pancreatic β-cells [193].