LEP and cancer: Moreover, adipose tissue may have an important impact on cancer cells residing in the neighboring tumor milieu. Some of the factors released via adipose tissue and adipose tissue macrophages that are related to cancer includes adiponectin, leptin, lipocalin 2, resistin, nicotinamide phosphoribosyltransferase, interleukin-6 (IL-6) and TNF-α [74].