PPARG and neoplasm: Different compounds of thiazolidinedione group exhibit different mechanism for their anti-tumor action, for instance, ciglitazone stimulates the expression of p21 and suppress the cyclin D1 by PPARγ independent pathways, while rosiglitazone acts through PPARγ dependent pathway to persuade the same effects in androgen-independent prostate carcinoma cells [246] (Fig. 9).