MYC and B-cell non-Hodgkin lymphoma: Double-hit lymphoma is high-grade B-cell lymphoma (HGBL) with MYC and B-Cell Leukaemia/Lymphoma (BCL)2 or BCL6 gene translocations detected by fluorescence in situ hybridization (FISH) or standard cytogenetics according to the National Comprehensive Cancer Network guidelines [9], representing a rare subtype with typical resistance to conventional therapy [10].