The highly connected (hub) targets in the functional module, such asNTRK1 (k = 43) and IMPDH2 (k = 37) in module1, as well as PLAT (k = 17) and COMT (k = 10) in module2, can be considered as potential targets for COVID-19 treatment (Additional file 1: Fig. S5). The gene discussed is PLAT; the disease is COVID-19.