Thereafter, m6A-qPCR was then used to confirm the abundance of m6A methylation in these positions and, furthermore that METTL3 induced LBX2-AS1 m6A hyper-methylation in the CRC cell lines (Additional file 1: Figure S1D and Fig. 3C). The gene discussed is LBX2-AS1; the disease is colorectal carcinoma.