Among the randomly selected women, women with PE and women with PPROM, the mean concentrations of fibulin-1 were 27.8 (17.0–36.0) μg/mL, 29.1 (19.0–37.0) μg/mL, and 15.4 (11.0-16.5) μg/mL, respectively. This evidence concerns the gene FBLN1 and preterm premature rupture of the membranes.