High expression of TRIM59 indicated poor prognosis in KIRP (HR 3.18; 95%CI 1.76–5.75), LGG (HR 1.98; 95%CI 1.39–2.83), LUAD (HR 1.40; 95%CI 1.04–1.88), lung cancer (GSE30219: HR 1.44; 95%CI 1.09–1.89; GSE31210: HR 2.37; 95%CI 1.22–4.60), and indicated good prognosis in CESC (HR 0.56; 95%CI 0.34–0.92) and SKCM (HR 0.71; 95%CI 0.54–0.92) (Fig 4). The gene discussed is TRIM59; the disease is lung carcinoma.