The results show that G40C (HR=3.89, 95% CI=1.39–10.87, p=0.01), advanced BCLC staging (HR=4.63, 95% CI=1.53–14.02, p=0.007), and high level of AFP (HR=5.88, 95% CI=1.88–18.39, p=0.002) significantly increased the risk of HCC recurrence in the group with postoperative antiviral treatment; however, G40C was not associated with postoperative recurrence in HCC patients without postoperative antiviral treatment (Supplementary Table 5). This evidence concerns the gene AFP and hepatocellular carcinoma.