The results show that tumor rupture (HR=3.91, 95% CI=1.14–13.35, p=0.03), microscopic vascular invasion (HR=3.03, 95% CI=1.72–5.34, p<0.001), α-fetoprotein (AFP) (HR=1.88, 95% CI=1.04–3.38, p=0.036), and ALP (HR=2.5, 95% CI=1.39–4.49, p=0.002) increased the risk of HCC recurrence, while age (HR=0.97, 95% CI=0.94–0.99, p=0.024) and antiviral treatment (HR=0.15, 95% CI=0.08–0.28, p<0.001) significantly decreased the risk of HCC recurrence (Supplementary Table 4). The gene discussed is AFP; the disease is hepatocellular carcinoma.