As AD progresses (stages III and IV), tau accumulation spreads into inferior and medial temporal lobes, as well as the posterior cingulum cortex before extending into the neocortex of the frontal and parietal lobes in the final stages (V and VI) of the disease (Braak & Braak, 1991; Braak et al., 2006; Braak et al., 2011). This evidence concerns the gene MAPT and Alzheimer disease.