While all hypertension guidelines recommend an initial combination of an ACE inhibitor/ARB with either a CCB or diuretic, beta-blockers may form part of the combination at any stage of treatment when they are specifically indicated, i.e., when a second comorbidity (CAD, symptomatic angina, myocardial infarction, heart failure, atrial fibrillation) is present [4]. The gene discussed is ACE; the disease is heart failure.