Furthermore, it was proven that F11R/JAM-A is involved in the development of several pathologies, such as cardiovascular diseases [96–99], inflammatory bowel disease [100], rheumatoid arthritis [101], neurological disorders [72, 102], reovirus infection [94, 103, 104], and various cancer types [66, 87, 88, 105–142]. Here, F11R is linked to nervous system disorder.