IGHE and allergic disease: Currently, the CDC recommends that individuals with a history of allergic reaction to any mRNA COVID-19 vaccine component or who experienced a severe allergic reaction to the first dose not take either FDA-authorized mRNA vaccine.9 The published data to date suggest that vaccination may be specifically contraindicated among patients with allergic reactions to PEG and/or P80.9 The data presented here, collected from a large regional health center, suggest that allergic reactions from the mRNA vaccines are likely owing to PEG and non–IgE-mediated mechanisms, likely CARPA.