We previously demonstrated that physiological expression of the tumor suppressor RASSF1A upon stem cell differentiation contributes to cell lineage determination (Papaspyropoulos et al, 2018) and that, conversely, epigenetic silencing of RASSF1A in cancer results in tumor microenvironment remodeling and display of cancer stemness properties (Pankova et al, 2019). The gene discussed is RASSF1; the disease is neoplasm.