Since IgE-dependent immune reactions to self-proteins have been already associated with AD by many authorities on the matter (Roesner and Werfel 2019; Tang et al. 2012; Zeller et al. 2009), it is tempting to speculate that autoimmune reactions towards self-Hsp90 play an important role in the pathogenesis of AD. Here, IGHE is linked to Alzheimer disease.