SIGLEC1 and infection: Two days after the first dose, i.e. at the time of infection with RMT or SBP-iRBCs (D0), flow cytometric analysis demonstrated that red pulp macrophages, CD169+ marginal metallophilic macrophages, and CCR2+ Ly6C+ inflammatory monocytes were fully depleted, and MARCO+ marginal zone macrophages and CCR2- Ly6C+ monocytes partially depleted.