A translational study we conducted in collaboration with the Fraunhofer Institute for Experimental Medicine and Toxicology (ITEM) in Hannover, Germany goes beyond the concept of “general secondary prevention” (data unpublished): To test whether basic skin therapy can protect against an episode of AD triggered by an inhalant allergen via the surrounding atmosphere, at least moderately grass pollen-rich IgE-sensitized patients with moderate-to-severe AD were exposed to a grass pollen-rich ambient atmosphere (corresponding to a summer meadow). Here, IGHE is linked to Alzheimer disease.