Assessments of patients with WNT1 osteoporosis, another rare, Wnt‐pathway‐related bone disease, revealed upregulation of two miRNAs and downregulation of six miRNAs.(28) Neither of the miRNAs differentially expressed in WNT1 osteoporosis overlapped with the miRNA profile identified in LRP5‐HBM individuals, possibly due to the bone anabolic effect of WNT1 being independent of LRP5.(29) Similarly, we did not observe overlap with miRNAs that were differentially expressed in osteoporotic patients with vertebral fractures.(22). This evidence concerns the gene LRP5 and osteoporosis.