This work also builds on efforts by other groups to connect osteoporosis‐reported GWAS signals directly to the transcription of a distal gene, and thus DS osteoblastogenesis.(28) Although additional studies are needed to further explore the regulation of EPDR1 via the ‘STARD3NL’ locus and to understand its mechanistic function, our cumulative data clearly point to EPDR1 being involved in bone differentiation processes and thus represents a new target for BMD‐related osteoporosis studies. The gene discussed is EPDR1; the disease is osteoporosis.