TF and hereditary hemochromatosis: In vitro, when osteoblasts are treated with free iron in the form of ferric ammonium citrate, this has shown to induce cell death as free iron can be toxic to cells.(57) Indeed, iron‐overload disorders studied in mice, including hereditary hemochromatosis, have been shown to have reduced bone compared with WT mice.(58) In this way, holo‐transferrin directly delivers iron through the transferrin‐receptor–mediated pathway reducing the accumulation of free iron.