Notably, however, in FIRE-3 cetuximab arm a small subgroup of BRAF-mutated tumors achieving an early tumor shrinkage ≥ 20% (9/17) showed significantly longer median PFS (9.0 vs. 1.9 months, log-rank test P = 0.002; HR = 0.14) and OS (29.8 vs. 5.9 months, log-rank test P = 0.047; HR = 0.3) than those not achieving it[53]. The gene discussed is BRAF; the disease is neoplasm.