More recently, gene expression analyses allowed to identify two different BRAF V600E subtypes in a large cohort of BRAF V600E mutated patients unselected for tumor stage: the BM1 subtype characterized by KRAS/AKT activation, mTOR/4EBP deregulation and EMT, and the BM2 subtype characterized by cell cycle and checkpoint pathway deregulation[46]. This evidence concerns the gene BRAF and neoplasm.