ECE1 and Alzheimer disease: Studies show that the ECE1 enzyme can act as a preventive measure against Alzheimer disease which is proved by studies done on Chinese hamster ovary cells where it was found that cells that have an overexpression of the ECE1 enzyme and lack endogenous ECE activity have the potential to reduce up to 90 percent amyloid β concentration; this effect can be antagonized by using the ECE1 inhibitor phosphoramidon.