Moreover, this type of association between CAC and periodontitis could be mediated through periodontal tissues induced by Porphyromonas gingivalis (P. gingivalis) cell wall lipopolysaccharide, which generating degradable apolipoprotein B-100, tumor necrosis factor-a (TNF-a), and interleukin-1β (IL-1β), causing changes in fat metabolism and eventually leading to the rise of blood lipid once it enters the blood circulation or deep tissue [45]. The gene discussed is TNF; the disease is periodontitis.