PPARG and glioblastoma: Interestingly, Chearwae and Bright (152) treated neurospheres generated from commercial GBM cell lines with the PPARγ agonists 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) or all-trans retinoic acid to induce apoptosis and inhibit neurosphere formation and expansion through Tyk2-Stat3 inhibition (152).