-↓ mitochondrial ATP production, ↓ oxygen consumption, ↑ lactate and glycolytic ATP production-↑AMPK, ↓ STAT3 & Akt/PKB-↓ SOX2 expression in TMZ-resistant glioma cells. (yang)-mTOR pathway inhibition-Inhibition of complex I of the ETC.-↓ superoxide dismutase (SOD) activity↑ caspase 3 activity. Here, AKT1 is linked to central nervous system cancer.