-Inhibition of ALDH.-Suppression of proteasomal activity.-↑ROS, activation of JNK & p38, inhibition of NF-κB in GBM cells.-Proposed modulation of apoptosis via Bcl2 family mediation.-Inhibition of PLK1 expression.-Inhibition of MGMT, ↑ alkylating DNA damage. This evidence concerns the gene PLK1 and glioblastoma.