demonstrated that neurodevelopmental transcription factors: sex determining region Y box 2 (SOX2), oligodendrocyte transcription factor (OLIG2), POU domain class 3 transcription factor 2 (POU3F2) and spalt like transcription factor 2 (SALL2) can be used to artificially reprogramme single cell primary glioblastoma cultures to a stem-like state, provides evidence for central nervous system (CNS) cell susceptibility to hierarchical reversal (35, 36). The gene discussed is SOX2; the disease is glioblastoma.