also suggested that miR-106a is involved in the progression of oral cancer by regulating E-cadherin, N-cadherin and Vimentin (39).In this study, we confirmed that overexpression of miR-199b-5p can promote EMT process by significantly reducing the level of E-cadherin and up regulating the expression of N-cadherin and Vimentin. These results were consistent with our in vivo and in vitro migration results. Here, CDH2 is linked to lip and oral cavity carcinoma.