Furthermore, exosomal miR-29a and miR-92a from glioblastoma cells promotes the proliferation and immunosuppressive phenotype of glioblastoma-infiltrating macrophages (GIMs) by targeting protein kinase cAMP-dependent type I regulatory subunit alpha and high-mobility group box transcription factor 1 (24). The gene discussed is PRKAR1A; the disease is glioblastoma.