Other aptamers have been tested including: (1) a STAT3 siRNA that successfully induces antitumor effects in glioblastoma when conjugated with a PDR3 aptamer against PDGFRα (104), and (2) a PDGFRβ–specific aptamer–siRNA chimera designated Gin4.T–STAT3 that could efficiently antagonize STAT3 in PDGFRβ+ GBM xenografts (103, 119). This evidence concerns the gene STAT3 and glioblastoma.