All patients underwent cell blood count, D-dimer, fibrinogen blood levels, and screening for known causes of hereditary thrombophilia (hyperhomocysteinemia, antiphospholipid antibodies, antithrombin III deficiency, protein S/C deficiency, factor V Leiden mutation, prothrombin mutation, activated protein C resistance). This evidence concerns the gene SERPINC1 and hyperinsulinemic hypoglycemia, familial, 4.