ASCEND-HF, Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure; TRUE-AHF, Trial of Ularitide Efficacy and Safety in Acute Heart Failure; RELAX-AHF-2, Relaxin in Acute Heart Failure-2 Trial; GALACTIC, Goal-Directed Afterload Reduction in Acute Congestive Cardiac Decompensation; ACE-I, angiotensin-converting enzyme inhibitor; ARBs, angiotensin receptor blockers; MOA, mechanism of action; PO, per oral; SL, sublingual; TD, transdermal. The gene discussed is ACE; the disease is hydrops fetalis.