The expressions of TNF‐α, the p‐NF‐κB p65/NF‐κB p65 ratio, and p‐IκBα/IκBα ratio were markedly increased in DM mice compared with normal mice (p < .05), which showed that diabetes significantly exacerbated the inflammatory stress in the hippocampus of mice. The gene discussed is NFKB1; the disease is diabetes mellitus.