As shown in Figures 7(c) and 7(d) and Table 3, there were seven KEGG pathways that were significantly associated with E2Fs similar genes in ccRCC : ko04110 (cell cycle), ko03460 (Fanconi anemia pathway), ko05168 (herpes simplex infection), ko04115 (p53 signaling pathway), hsa03040 (spliceosome), ko00310 (lysine degradation), and hsa05161 (hepatitis B). Here, TP53 is linked to nonpapillary renal cell carcinoma.