As shown in Figures 7(c) and 7(d) and Table 3, there were seven KEGG pathways that were significantly associated with E2Fs similar genes in ccRCC : ko04110 (cell cycle), ko03460 (Fanconi anemia pathway), ko05168 (herpes simplex infection), ko04115 (p53 signaling pathway), hsa03040 (spliceosome), ko00310 (lysine degradation), and hsa05161 (hepatitis B). This evidence concerns the gene TP53 and herpes simplex infectious disease.