E2F1 and neoplasm: Ma et al. [9] have first reported that the mRNA level of E2F1 in renal clear cell carcinoma tissue is related to tumor pathological parameters, including diameter, Fuhrman tumor grade, pT staging, TNM staging and macrovascular infiltration (MAVI), and E2F1 expression with the increase of tumor tissue grade; they also found that E2F1 has promoting effects on the proliferation, migration, and invasion of cancer cells.