As shown in Figures 7(c) and 7(d) and Table 3, there were seven KEGG pathways that were significantly associated with E2Fs similar genes in ccRCC : ko04110 (cell cycle), ko03460 (Fanconi anemia pathway), ko05168 (herpes simplex infection), ko04115 (p53 signaling pathway), hsa03040 (spliceosome), ko00310 (lysine degradation), and hsa05161 (hepatitis B). The gene discussed is TP53; the disease is hepatitis B virus infection.