Detecting the expression of Nrf2 and HO-1 in the brain tissue of experimental cerebral infarction rats found that the expression of Nrf2, HO-1 protein, and mRNA in the brain tissue of the model group decreased, indicating that in the brain tissue of experimental cerebral infarction rats, Nrf2, HO-1 is at a low level. This evidence concerns the gene HMOX1 and brain infarction.