And a newly published study from the United States put out a novel antifibrotic approach directly targeting signal transducer and activator of transcription 3 (STAT3), which was an important transcription factor associated with liver fibrosis, and this process was accomplished based on the administration of MSCs-derived exosomes embedded with small interference RNAs and antisense oligonucleotides [107]. Here, STAT3 is linked to Hepatic fibrosis.